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Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes.

Authors
  • Huen, Jennifer1
  • Kakihara, Yoshito
  • Ugwu, Francisca
  • Cheung, Kevin L Y
  • Ortega, Joaquin
  • Houry, Walid A
  • 1 Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. , (Canada)
Type
Published Article
Journal
Biochemistry and Cell Biology
Publisher
Canadian Science Publishing
Publication Date
Feb 01, 2010
Volume
88
Issue
1
Pages
29–40
Identifiers
DOI: 10.1139/o09-122
PMID: 20130677
Source
Medline
License
Unknown

Abstract

Rvb1 and Rvb2 are highly conserved, essential AAA+ helicases found in a wide range of eukaryotes. The versatility of these helicases and their central role in the biology of the cell is evident from their involvement in a wide array of critical cellular complexes. Rvb1 and Rvb2 are components of the chromatin-remodeling complexes INO80, Swr-C, and BAF. They are also members of the histone acetyltransferase Tip60 complex, and the recently identified R2TP complex present in Saccharomyces cerevisiae and Homo sapiens; a complex that is involved in small nucleolar ribonucleoprotein (snoRNP) assembly. Furthermore, in humans, Rvb1 and Rvb2 have been identified in the URI prefoldin-like complex. In Drosophila, the Polycomb Repressive complex 1 contains Rvb2, but not Rvb1, and the Brahma complex contains Rvb1 and not Rvb2. Both of these complexes are involved in the regulation of growth and development genes in Drosophila. Rvbs are therefore crucial factors in various cellular processes. Their importance in chromatin remodeling, transcription regulation, DNA damage repair, telomerase assembly, mitotic spindle formation, and snoRNP biogenesis is discussed in this review.

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