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Russian-Doll-Like Molecular Cubes.

Authors
  • Liu, Die1
  • Li, Kaixiu2
  • Chen, Mingzhao1
  • Zhang, Tingting1
  • Li, Zhengguang2
  • Yin, Jia-Fu3
  • He, Lipeng4
  • Wang, Jun2
  • Yin, Panchao3
  • Chan, Yi-Tsu4
  • Wang, Pingshan1, 2
  • 1 Institute of Environmental Research at Greater Bay Area; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education; Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, China. , (China)
  • 2 Department of Organic and Polymer Chemistry; Hunan Key Laboratory of Micro & Nano Materials Interface Science; College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China. , (China)
  • 3 South China Advanced Institute for Soft Matter Science and Technology & State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China. , (China)
  • 4 Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan. , (Taiwan)
Type
Published Article
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Publication Date
Feb 17, 2021
Volume
143
Issue
6
Pages
2537–2544
Identifiers
DOI: 10.1021/jacs.0c11703
PMID: 33378184
Source
Medline
Language
English
License
Unknown

Abstract

Nanosized cage-within-cage compounds represent a synergistic molecular self-assembling form of three-dimensional architecture that has received particular research focus. Building multilayered ultralarge cages to simulate complicated virus capsids is believed to be a tough synthetic challenge. Here, we synthesize two large double-shell supramolecular cages by facile self-assembly of presynthesized metal-organic hexatopic terpyridine ligands with metal ions. Differing from the mixture of prisms formed from the inner tritopic ligand, the redesigned metal-organic hexatopic ligands bearing high geometric constraints that led to the exclusive formation of discrete double-shell structures. These two unique nested cages are composed of inner cubes (5.1 nm) and outer huge truncated cubes (12.0 and 13.2 nm) with six large bowl-shape subcages distributed on six faces. The results with molecular weights of 75 232 and 77 667 Da were among the largest synthetic cage-in-cage supramolecules reported to date. The composition, size and shape were unambiguously characterized by a combination of 1H NMR, DOSY, ESI-MS, TWIM-MS, TEM, AFM, and SAXS. This work provides an interesting model for functional recognition, delivery, and detection of various guest molecules in the field of supramolecular materials.

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