The article analyzes and comments on the results of a regular inquiry carried out by the Institute of Economic Forecasting of Russian Academy of Sciences. Data on the macroeconomic problems that create the greatest difficulties for Russian enterprises and what methods the enterprises use to solve their financial and marketing problems, as well as to reduce their production costs are presented. Opinions of Russian enterprises on the consequences of expected economic sanctions against Russia and of countersanctions against foreign countries are reflected. Comparative evaluations of the quality of domestic machinery and equipment of Russian enterprises are considered. Information on the nature of enterprises and banks’ cooperation is presented. The situation with human resources is considered.