Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.
UNC Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC, 27599, USA.
Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, The University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC, 27599, USA.
UNC Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC, 27599, USA. Electronic address: [email protected]
- Published Article
- Publication Date
Jan 02, 2020
KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time. Additionally, it compared the cytokine profiles of the KICS case to Kaposi's sarcoma (KS) (n = 11) and non-KS (n = 6) cases. This KICS case presented with elevated levels of KSHV and IL-10, as expected. Surprisingly, this case did not have elevated levels of IL-6 or human immunodeficiency virus 1 (HIV-1). Nevertheless, treatment with anti-IL6 receptor antibody (tocilizumab) reduced KSHV viral load and IL-10. The KSHV genome sequence showed no significant changes over time, except in ORF24. Phylogenetic analysis established this isolate as belonging to KSHV clade A and closely related to other US isolates. These findings suggest IL-10 as potential biomarker and therapy target for KICS. Copyright © 2019 Elsevier Inc. All rights reserved.
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This record was last updated on 12/31/2019 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31629226