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RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter.

Authors
Type
Published Article
Journal
Synapse
0887-4476
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
30
Issue
1
Pages
49–55
Identifiers
PMID: 9704880
Source
Medline

Abstract

RTI-113 [3beta-(4-chlorophenyl)tropan-2beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT.

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