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Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

Authors
  • Clément, Olivier1, 2
  • Hemming, Isabel Anne1, 2
  • Gladwyn-Ng, Ivan Enghian1, 2
  • Qu, Zhengdong3
  • Li, Shan Shan3
  • Piper, Michael4, 5
  • Heng, Julian Ik-Tsen6, 7, 8, 9
  • 1 The Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia. , (Australia)
  • 2 The Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia. , (Australia)
  • 3 EMBL Australia, The Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia. , (Australia)
  • 4 The School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia. , (Australia)
  • 5 Queensland Brain Institute, University of Queensland, Brisbane, 4072, Australia. , (Australia)
  • 6 The Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia. [email protected] , (Australia)
  • 7 The Centre for Medical Research, University of Western Australia, Perth, WA, 6009, Australia. [email protected] , (Australia)
  • 8 EMBL Australia, The Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia. [email protected] , (Australia)
  • 9 Curtin Health Innovation Research Institute, Curtin University, Bentley, 6845, Australia. [email protected] , (Australia)
Type
Published Article
Journal
Neural Development
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 15, 2017
Volume
12
Issue
1
Pages
8–8
Identifiers
DOI: 10.1186/s13064-017-0084-3
PMID: 28506232
Source
Medline
Keywords
License
Unknown

Abstract

Our findings demonstrate functional interplay between a transcriptional regulator and a CDKI to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA signalling.

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