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Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19

Authors
  • Kristem, Leonardo1
  • Recamonde-Mendoza, Mariana2, 1
  • Cigerza, Giuliano C.1
  • Khoraki, Jad3
  • Campos, Guilherme M.3
  • Mazzini, Guilherme S.1, 3
  • 1 Hospital de Clínicas de Porto Alegre,
  • 2 Universidade Federal do Rio Grande do Sul,
  • 3 Virginia Commonwealth University,
Type
Published Article
Journal
Obesity Surgery
Publisher
Springer-Verlag
Publication Date
Feb 21, 2021
Pages
1–4
Identifiers
DOI: 10.1007/s11695-021-05271-7
PMID: 33611766
PMCID: PMC7896878
Source
PubMed Central
Keywords
License
Unknown

Abstract

The angiotensin-converting enzyme 2 (ACE2) is the receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is highly expressed in adipose tissue, possibly associated with progression to severe coronavirus disease 2019 (COVID-19) in obese subjects. We searched the Gene Expression Omnibus (GEO) and reanalyzed the GSE59034 containing microarray data from subcutaneous white adipose tissue (sWAT) biopsies from 16 women before and 2 years after RYGB, and 16 controls matched by sex, age, and BMI. After RYGB, there was a significant decrease in sWAT ACE2 gene expression (logFC=-0.4175, P =0.0015). Interestingly, after RYGB the sWAT ACE2 gene expression was significantly lower than in non-obese matched controls (LogFC=-0.32875, P =0.0014). Our data adds to the well-known benefits of RYGB, a potential protective mechanism against COVID-19.

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