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Rotational dynamics of bases in the gene coding interferon alpha 17 (IFNA17).

Authors
  • Krasnobaeva, L A1
  • Yakushevich, L V
  • 1 Department of Theoretical Physics, Tomsk State University, Pr. Lenina 36, Tomsk 634050, Russia , Department of Physics, Siberian State Medical University, 2, Moscowski Trakt St., Tomsk, 634050, Russia.
Type
Published Article
Journal
Journal of bioinformatics and computational biology
Publication Date
Feb 01, 2015
Volume
13
Issue
1
Pages
1540002–1540002
Identifiers
DOI: 10.1142/S0219720015400028
PMID: 25556701
Source
Medline
Keywords
License
Unknown

Abstract

In the present work, rotational oscillations of nitrogenous bases in the DNA with the sequence of the gene coding interferon alpha 17 (IFNA17), are investigated. As a mathematical model simulating oscillations of the bases, we use a system of two coupled nonlinear partial differential equations that takes into account effects of dissipation, action of external fields and dependence of the equation coefficients on the sequence of bases. We apply the methods of the theory of oscillations to solve the equations in the linear approach and to construct the dispersive curves determining the dependence of the frequency of the plane waves (ω) on the wave vector (q). In the nonlinear case, the solutions in the form of kink are considered, and the main characteristics of the kink: the rest energy (E0), the rest mass (m0), the size (d) and sound velocity (C0), are calculated. With the help of the energetic method, the kink velocity (υ), the path (S), and the lifetime (τ) are also obtained.

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