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Cognitive Improvement Effects of Electroacupuncture Combined with Computer-Based Cognitive Rehabilitation in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial.

Authors
  • Kim, Jae-Hong1, 2
  • Han, Jae-Young3
  • Park, Gwang-Cheon2
  • Lee, Jeong-Soon4
  • 1 Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, DongShin University, Naju City 58245, Korea. , (North Korea)
  • 2 Clinical Research Center, DongShin University Gwangju Korean Medicine Hospital, 141, Wolsan-ro, Nam-gu, Gwangju City 61619, Korea. , (North Korea)
  • 3 Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School and Hospital, Gwangju City 61469, Korea. , (North Korea)
  • 4 Department of Nursing, Christian College of Nursing, Gwangju City 61662, Korea. , (North Korea)
Type
Published Article
Journal
Brain Sciences
Publisher
MDPI AG
Publication Date
Dec 14, 2020
Volume
10
Issue
12
Identifiers
DOI: 10.3390/brainsci10120984
PMID: 33327627
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This outcome assessor-blinded, randomized controlled clinical trial investigated the effects of electroacupuncture combined with computer-based cognitive rehabilitation (EA-CCR) on mild cognitive impairment (MCI). A per-protocol analysis was employed to compare the efficacy of EA-CCR to that of computer-based cognitive rehabilitation (CCR). Thirty-two patients with MCI completed the trial (EA-CCR group, 16; CCR group, 16). Patients received EA-CCR or CCR treatment once daily three days per week for eight weeks. Outcome (primary, ADAS-K-cog; secondary, MoCA-K, CES-D, K-ADL, K-IADL, and EQ-5D-5L) measurements were performed at baseline (week 0), at the end of the intervention (week 8), and at 12 weeks after completion of the intervention (week 20). Both groups showed significant changes in ADAS-K-cog score (EA-CCR, p < 0.001; CCR, p < 0.001) and MoCA-K (EA-CCR, p < 0.001; CCR, p < 0.001). Only the EA-CCR group had a significant change in CES-D (p = 0.024). No significant differences in outcomes and in the results of a subanalysis based on age were noted between the groups. These results indicate that EA-CCR and CCR have beneficial effects on improving cognitive function in patients with MCI. However, electroacupuncture in EA-CCR showed no positive add-on effects on improving cognitive function, depression, activities of daily living, and quality of life in patients with MCI.

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