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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Authors
  • Venken, Koen1, 2
  • Jacques, Peggy1, 2
  • Mortier, Céline1, 2
  • Labadia, Mark E.3
  • Decruy, Tine1, 2
  • Coudenys, Julie1, 2
  • Hoyt, Kathleen3
  • Wayne, Anita L.3
  • Hughes, Robert3
  • Turner, Michael3
  • Van Gassen, Sofie2, 4
  • Martens, Liesbet2, 4
  • Smith, Dustin3
  • Harcken, Christian3
  • Wahle, Joseph3
  • Wang, Chao-Ting3
  • Verheugen, Eveline1, 2
  • Schryvers, Nadia1, 2
  • Varkas, Gaëlle1, 2
  • Cypers, Heleen1, 2
  • And 8 more
  • 1 Ghent University, Department of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, C. Heymanslaan 10, Ghent, 9000, Belgium , Ghent (Belgium)
  • 2 Ghent University, VIB Inflammation Research Center, Technologiepark 71, Ghent, 9052, Belgium , Ghent (Belgium)
  • 3 Research and Development Boehringer-Ingelheim, 175 Briar Ridge Road, Ridgefield, CT, 06877, USA , Ridgefield (United States)
  • 4 Ghent University, Department of Applied Mathematics, Computer Science and Statistics, Technologiepark 71, Ghent, 9052, Belgium , Ghent (Belgium)
  • 5 AZ SintJan, Ruddershove 10, Brugge, 8000, Belgium , Brugge (Belgium)
  • 6 ASZ Aalst, Merestraat 80, Aalst, 9300, Belgium , Aalst (Belgium)
  • 7 Ghent University, Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ottergemsesteenweg 460, Gent, 9052, Belgium , Gent (Belgium)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Jan 02, 2019
Volume
10
Issue
1
Identifiers
DOI: 10.1038/s41467-018-07911-6
Source
Springer Nature
License
Green

Abstract

The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.

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