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Ropivacaine pharmacokinetics after local infiltration analgesia in hip arthroplasty.

Authors
  • Affas, Fatin
  • Eksborg, Staffan
  • Wretenberg, Per
  • Olofsson, Christina
  • Stiller, Carl-Olav
Type
Published Article
Journal
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer) - Anesthesia & Analgesia
Publication Date
Oct 01, 2014
Volume
119
Issue
4
Pages
996–999
Identifiers
DOI: 10.1213/ANE.0000000000000364
PMID: 25025588
Source
Medline
License
Unknown

Abstract

In this study, we determined the plasma concentration of ropivacaine by liquid chromatography-mass spectrometry for 30 hours after local infiltration analgesia in 15 patients with elective hip arthroplasty. The 95% upper prediction bound of maximal unbound plasma concentration of ropivacaine was 0.032 mg/L. Side effects sufficient to stop an IV infusion have been reported at arterial concentrations of 0.34 to 0.85 mg/L. Alpha-1-acid glycoprotein did not correlate with the fraction of unbound ropivacaine during the first 24 hours after local infiltration analgesia. No signs or symptoms of systemic local anesthetic toxicity were observed. The Clopper-Pearson 95% upper confidence limit for adverse signs was 0.218.

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