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Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis.

Authors
  • Cursiefen, Claus
  • Masli, Sharmila
  • Ng, Tat Fong
  • Dana, M Reza
  • Bornstein, Paul
  • Lawler, Jack
  • Streilein, J Wayne
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Apr 01, 2004
Volume
45
Issue
4
Pages
1117–1124
Identifiers
PMID: 15037577
Source
Medline
License
Unknown

Abstract

Corneal avascularity during development is redundantly regulated, shown by the fact that lack of the antiangiogenic factors TSP-1 and/or -2 resulted in no spontaneous corneal angiogenesis. By contrast, TSP-1, more than TSP-2, helps to suppress inflammation-induced corneal angiogenesis postnatally, implying that angiogenic privilege in the cornea is actively maintained.

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