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Roles of SMC Complexes During T Lymphocyte Development and Function.

Authors
  • Rawlings, J S1
  • 1 Furman University, Greenville, SC, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Advances in protein chemistry and structural biology
Publication Date
Jan 01, 2017
Volume
106
Pages
17–42
Identifiers
DOI: 10.1016/bs.apcsb.2016.08.001
PMID: 28057211
Source
Medline
Keywords
License
Unknown

Abstract

T lymphocytes (T cells) comprise a critical component of the immune system charged with diverse functions during an immune response. As a function of maturation in the thymus, T cells become quiescent and remain so until they participate in an immune response in the periphery. Recent work indicates that the control of T cell proliferation is mediated, at least in part, by chromatin architecture. Quiescent T cells possess a condensed chromatin, whereas proliferating T cells have a more open chromatin configuration. The structural maintenance of chromosome (SMC) complexes, which include Cohesin and Condensin, have long been known to play roles in modulating chromatin architecture during cell division; however, they are now known to have additional roles during interphase biology. These roles include the large-scale reorganization of chromatin as well as the regulation of specific gene loci. This review focuses on the roles that SMC complexes play in T cell development and function.

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