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Roles of potassium channels and nitric oxide in modulation of uterine contractions in rat pregnancy.

Authors
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
0002-9378
Publisher
Elsevier
Publication Date
Volume
181
Issue
3
Pages
649–655
Identifiers
PMID: 10486479
Source
Medline

Abstract

There is gestational age-dependent refractoriness to calcium-dependent potassium but not adenosine triphosphate-dependent potassium channel opener-induced inhibition of spontaneous contractile activity of isolated rat uterine rings. Nitric oxide inhibits uterine contractions by opening of calcium-dependent potassium channels in pregnant rat myometrium. Refractoriness to nitric oxide toward term may result from decreased probability to open or number of calcium-dependent potassium channels.

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