Affordable Access

Roles of potassium channels and nitric oxide in modulation of uterine contractions in rat pregnancy.

Authors
  • Okawa, T
  • Vedernikov, Y P
  • Saade, G R
  • Longo, M
  • Olson, G L
  • Chwalisz, K
  • Garfield, R E
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
Publisher
Elsevier
Publication Date
Sep 01, 1999
Volume
181
Issue
3
Pages
649–655
Identifiers
PMID: 10486479
Source
Medline
License
Unknown

Abstract

There is gestational age-dependent refractoriness to calcium-dependent potassium but not adenosine triphosphate-dependent potassium channel opener-induced inhibition of spontaneous contractile activity of isolated rat uterine rings. Nitric oxide inhibits uterine contractions by opening of calcium-dependent potassium channels in pregnant rat myometrium. Refractoriness to nitric oxide toward term may result from decreased probability to open or number of calcium-dependent potassium channels.

Report this publication

Statistics

Seen <100 times