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Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to β-Lactams

Authors
  • Kunihiko Nishino
  • Junko Yamada
  • Hidetada Hirakawa
  • Takahiro Hirata
  • Akihito Yamaguchi
Publisher
American Society for Microbiology
Publication Date
Sep 01, 2003
Source
PMC
Keywords
License
Unknown

Abstract

AcrAB exports some β-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in β-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer β-lactam antibiotic resistance, while no other drug exporters confer any β-lactam resistance even when they cooperate with TolC.

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