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Roles for LBP and soluble CD14 in cellular uptake of LPS.

Authors
  • Tapping, R I1
  • Gegner, J A
  • Kravchenko, V V
  • Tobias, P S
  • 1 Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
Type
Published Article
Journal
Progress in clinical and biological research
Publication Date
Jan 01, 1998
Volume
397
Pages
73–78
Identifiers
PMID: 9575548
Source
Medline
Language
English
License
Unknown

Abstract

Roles for LBP and CD14 in the LPS dependent activation of a wide variety of cells have been established. In the work described here, we describe roles for these proteins in the binding and uptake of LPS by cells which express membrane CD14 and those which do not. Surprisingly, cell activation and LPS uptake appear to be independent phenomena with different protein requirements.

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