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Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine.

Authors
  • Wang, Dawei1, 2
  • Yu, Weiqing3
  • Liu, Yuntao1, 2
  • Zhong, Guofu1
  • Zhao, Zhen1
  • Yan, Xia1, 2
  • Liu, Qing1, 4
  • 1 * The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. , (China)
  • 2 † Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510405, China. , (China)
  • 3 ‡ Department of Cardiology, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510095, China. , (China)
  • 4 § Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. , (China)
Type
Published Article
Journal
The American journal of Chinese medicine
Publication Date
Jan 01, 2017
Volume
45
Issue
7
Pages
1401–1419
Identifiers
DOI: 10.1142/S0192415X17500768
PMID: 28946768
Source
Medline
Keywords
License
Unknown

Abstract

Autophagy is an evolutionarily conserved degradation process which eliminates dysfunctional proteins and cytoplasmic components to maintain homeostasis for cell survival. Increasing evidence has demonstrated the modulatory role of autophagy in ischemic heart diseases (IHDs). Traditionally, this process has been recognized as having protective functions, such as inhibiting atherosclerosis progression and reducing cell death during the ischemic phase. However, recent studies have suggested its dual roles in myocardial ischemia/reperfusion (MIR) injury. Excessive autophagy may play a deleterious role in cardiac function, due to overwhelming clearance of cellular constituents and proteins. Hence modulation of autophagy to increase cardiomyocyte survival and improve cardiac function is meaningful for the treatment of IHD. Chinese herbal medicine, including extractive compounds and patented drugs, has shown its potential role in treating IHD by addressing autophagy-related mechanisms. This review summarizes the updated knowledge on the molecular basis and modulatory role of autophagy in IHD and the recent progress of Chinese herbal medicine in its treatment.

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