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The role of von Willebrand factor in platelet function.

Authors
  • de Groot, Philip G
Type
Published Article
Journal
Seminars in thrombosis and hemostasis
Publication Date
Apr 01, 2002
Volume
28
Issue
2
Pages
133–138
Identifiers
PMID: 11992236
Source
Medline
License
Unknown

Abstract

von Willebrand factor (vWF) has essential functions in the very first stage of hemostasis. At the site of vascular damage vWF binds immediately to exposed collagens, thereby facilitating the adhesion of platelets. After a first layer of platelets has been formed, vWF is also crucial as a link between platelets in the forming thrombus. In this article, the current knowledge on the role of vWF in primary hemostasis is reviewed.

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