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Role of vitamin D in risk factors of patients with type 2 diabetes mellitus.

Authors
  • Zhang, Qingqing1
  • Wu, Yucheng2
  • Lu, Yu3
  • Fei, Xiaoqiang3
  • 1 Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China. Electronic address: [email protected] , (China)
  • 2 Department of Cardiology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China. , (China)
  • 3 Department of Endocrinology, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou 225300, Jiangsu, China. , (China)
Type
Published Article
Journal
Medicina Clínica
Publisher
Elsevier
Publication Date
Mar 13, 2020
Volume
154
Issue
5
Pages
151–156
Identifiers
DOI: 10.1016/j.medcli.2019.04.019
PMID: 31255367
Source
Medline
Keywords
Language
Spanish
License
Unknown

Abstract

Previous observational studies have suggested that low vitamin D status is associated with high circulating C-reactive protein levels, as well as other plasma inflammatory cytokines. However, there is no study to explore the relationship between vitamin D status and Lp-PLA2, a new biomarker of vascular-specific inflammation. The aim of this study was to examine the association between vitamin D status and circulating Lp-PLA2 levels in subjects with type 2 diabetes mellitus. This descriptive cross-sectional study enrolled diabetic subjects who underwent physical examination at Taizhou People's Hospital between August 2016 and January 2017. Blood pressure, anthropometry, metabolic profiles, serum 25(OH)D levels and Lp-PLA2 mass levels were measured in all participants. A total of 196 participants were recruited into this study. The vitamin D insufficiency group had higher serum LP-PLA2 levels than the vitamin D sufficiency group (t=-2.765, p=.005). A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=-0.364, p=0.009). However, no significant relationship between serum Lp-PLA2 concentration and 25(OH)D levels was observed in subjects with vitamin D sufficiency. From this cohort of patients with type 2 diabetes, regardless of traditional cardiovascular risk factors, we observed a statistically significant inverse relation between Lp-PLA2 and 25(OH)D at levels <30ng/mL. Copyright © 2019 Elsevier España, S.L.U. All rights reserved.

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