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[Role of transforming growth factor-beta in the development of some liver diseases].

Authors
Type
Published Article
Journal
Terapevticheskiĭ arkhiv
Publication Date
Volume
86
Issue
2
Pages
44–48
Identifiers
PMID: 24772507
Source
Medline
License
Unknown

Abstract

The enhanced TGF-beta1 expression in the nonparenchymal liver cells in AIH and PBC with liver cirrhosis confirms the role of this cytokine in development of fibrosis in autoimmune liver diseases. That in hepatitis of various etiologies versus PBC suggests that the TGF-beta1 signaling pathway may play an important role in an inappropriate immune response in hepatitides; and the variations found in the location of the macrophages expressing TGF-beta1 reflect a difference in the mechanisms of lesions.

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