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Role of therapeutic drug monitoring for protease inhibitors.

Authors
Type
Published Article
Journal
The Annals of pharmacotherapy
Publication Date
Volume
35
Issue
6
Pages
745–754
Identifiers
PMID: 11408994
Source
Medline

Abstract

A number of clinical studies support the usefulness of TDM of protease inhibitors. However, before TDM can be of the most value, further evaluation requires simplified and standardized assays to be performed routinely by clinical laboratories; determination of the appropriate target concentration and therapeutic range, as well as the best predictor of pharmacologic response; and refined interpretation of plasma drug concentrations. Randomized, controlled clinical trials of patient outcomes are needed to assess the clinical utility of TDM for protease inhibitors.

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