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[The role of the sympathetic cholinergic pathway in the neurogenic control of the release of tissue-type plasminogen activator into the blood].

Authors
  • Bashkov, G B
  • Sergeev, I Iu
  • Medvedeva, N A
  • Makarov, V A
Type
Published Article
Journal
Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
Publication Date
May 01, 1992
Volume
78
Issue
5
Pages
60–67
Identifiers
PMID: 1334882
Source
Medline
License
Unknown

Abstract

In anesthetized cats, electric stimulation of the sympathetic chain induced vasoconstriction and release of t-PA from the vascular wall into the blood. Efferent stimulation of the sympathetic chain against the background of alpha-adrenoceptor blockade increased the blood flow and the t-PA activity. Atropin suppressed both the vascular relaxation and the t-PA release into the blood. A neurogenous mechanism controlling t-PA release from the vascular wall caused by activation of sympathetic cholinergic pathway and associated with excitation of vascular M-cholinoreceptors by acetylcholine, has been suggested.

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