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The role of suppressors of cytokine signalling in thymopoiesis and T cell activation.

Authors
  • Fletcher, Joel
  • Starr, Robyn
Type
Published Article
Journal
The International Journal of Biochemistry & Cell Biology
Publisher
Elsevier
Publication Date
Sep 01, 2005
Volume
37
Issue
9
Pages
1774–1786
Identifiers
PMID: 15905116
Source
Medline
License
Unknown

Abstract

Cytokines play an essential role in mediating interactions between cells of the immune system. Suppressors of cytokine signalling proteins act to negatively regulate these cytokine signals, thereby exerting control over the expression of cytokine responsive genes. Various lines of experimental evidence suggest that two closely related members of the this family, suppressor of cytokine signalling 1 and 3, are important in the processes of T cell development, activation and homeostasis. This review outlines the principles underlying these processes and relates these to the potentially important roles played by suppressor of cytokine signalling 1 and 3.

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