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The role of serum nuclear factor erythroid 2-related factor 2 in childhood bronchial asthma.

Authors
  • Youness, Eman Refaat1
  • Shady, Mones2
  • Nassar, Maysa Samir2
  • Mostafa, Rehab2
  • Abuelhamd, Walaa3
  • 1 Medical Biochemistry, National Research Centre, Cairo, Egypt. , (Egypt)
  • 2 Child Health, National Research Centre, Cairo, Egypt. , (Egypt)
  • 3 Neonatology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt. , (Egypt)
Type
Published Article
Journal
Journal of Asthma
Publisher
Informa UK (Taylor & Francis)
Publication Date
Apr 01, 2020
Volume
57
Issue
4
Pages
347–352
Identifiers
DOI: 10.1080/02770903.2019.1571081
PMID: 30729848
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Background: Asthma is one of the most common chronic airway disease of childhood. Poor asthma control has been associated with antioxidant deficiencies. Objective: To assess the association of bronchial asthma in Egyptian children with serum nuclear factor erythroid 2-related factor2 (NRF2) and its relation to disease severity. Subjects and methods: The study included 60 asthmatic children with comparable 60 controls (age ranged from 6-16 years). Subjects were classified according to the severity of asthma into mild or moderate asthma in group I, and severe asthma in group II. Antioxidant markers including superoxide-dismutase (SOD), glutathione peroxidase (GPX) and NRF2 were assessed once in blood and serum of both subjects and controls. Results: Mean serum NRF2 and GPX were significantly lower in asthmatic group than controls group (26.36 ± 4.18 pg/mL and 5.76 ± 0.81 mU/mL vs 29.05 ± 3.87 and 6.23 ± 0.97 respectively, p < 0.05). No significant difference was detected regarding SOD (p > 0.05). In severe bronchial asthma, mean serum NRF2 and GPX were significantly lower than in mild and moderate asthma (24.29 ± 1.86 pg/mL and 5.56 ± 0.67 mU/mL vs 27.95 ± 4.77 and 6.03 ± 0.90 respectively, p < 0.05). No significant difference was found in SOD regarding severity of bronchial asthma. Low NRF2 was the only predictor of the severity of bronchial asthma (OR = 0.749 and 95% CI 0.595 - 0.942). Conclusion: The pathogenesis of childhood bronchial asthma may be associated with low serum NRF2 which may be a strong predictor of the disease severity.

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