Affordable Access

Access to the full text

The Role of Serum Albumin in the Conduction of a Regulatory Signal in Mammals

Authors
  • Krasnov, M. S.1
  • Ilyina, A. P.2
  • Yamskova, V. P.2
  • 1 Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia , Moscow (Russia)
  • 2 Institute of Problems of Bioregulation, Moscow, Russia , Moscow (Russia)
Type
Published Article
Journal
Biology Bulletin Reviews
Publisher
Pleiades Publishing
Publication Date
Dec 01, 2021
Volume
11
Issue
Suppl 1
Pages
19–31
Identifiers
DOI: 10.1134/S2079086421070057
Source
Springer Nature
Keywords
Disciplines
  • Article
License
Yellow

Abstract

Abstract—This review presents data on the study of the structure, physicochemical properties, and biological activity of extracellular protein-peptide complexes that participate in intercellular adhesion and activate cellular sources of regeneration in vertebrate tissues. Protein-peptide complex consists of certain isoforms of serum albumin and peptides—products of the proteolysis of known membrane and adhesion proteins. The biological effect of protein-peptide complexes is characterized by the presence of tissue specificity and dose dependence but a lack of species specificity. In solutions, protein-peptide complexes are in the form of nanosized particles; this state is associated with the manifestation of biological activity of the protein-peptide complex. A possible mechanism of the protein-peptide complex structure and its interaction with the cell plasma membrane is considered.

Report this publication

Statistics

Seen <100 times