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Role of selectins and fibrinolysis in VTE.

Authors
  • Wakefield, Thomas W
  • Myers, Daniel D
  • Henke, Peter K
Type
Published Article
Journal
Thrombosis Research
Publisher
Elsevier
Publication Date
Jan 01, 2009
Volume
123 Suppl 4
Identifiers
DOI: 10.1016/S0049-3848(09)70141-0
PMID: 19303502
Source
Medline
License
Unknown

Abstract

Venous thromboembolism (VTE) accounts for an estimated 900,000 cases of deep venous thrombosis (DVT) and pulmonary embolism (PE) yearly, resulting in approximately 300,000 deaths [1]. For the past 150 years, Virchow's triad has encompassed the elements of venous thrombogenesis, including stasis, changes in the vessel wall, and thrombogenic changes in the blood. However, in the early 1970s, through the work of Gwendylen Stewart, a relationship between thrombosis and inflammation was suggested. In this review, we will address the role of selectins and fibrinolysis in the process of venous thrombogenesis.

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