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[The Role of Segmental Analysis of Clonazepam in Hair in Drug Facilitated Cases].

Authors
  • Chen, H1
  • Xiang, P1
  • Shen, M1
  • 1 Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, PRC, Shanghai 200063, China. , (China)
Type
Published Article
Journal
Fa yi xue za zhi
Publication Date
Jun 01, 2017
Volume
33
Issue
3
Pages
252–257
Identifiers
DOI: 10.3969/j.issn.1004-5619.2017.03.008
PMID: 29230989
Source
Medline
Keywords
Language
Chinese
License
Unknown

Abstract

To infer the frequency of dosage and medication history investigate of the victims in drug facilitated cases by the segmental analysis of clonazepam in hair. Freezing milling under liquid nitrogen environment combined with ultrasonic bath was used as sample pretreatment in this study, and liquid chromatography-tandem mass spectrometry was used for the segmental analysis of the hair samples collected from 6 victims in different cases. The concentrations of clonazepam and 7-aminoclonazepam were detected in each hair section. Clonazepam and its metabolite 7-aminoclonazepam were detected in parts of hair sections from the 6 victims. The occurrence time of drug peak concentration was consistent with the intake timing provided by victims. Segmental analysis of hair can provide the information of frequency of dosage and intake timing, which shows an unique evidential value in drug facilitated crimes. Copyright© by the Editorial Department of Journal of Forensic Medicine

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