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The role of SCF ubiquitin-ligase complex at the beginning of life

Authors
  • Xie, Jiayan1, 2
  • Jin, Yimei3
  • Wang, Guang1
  • 1 Jinan University, Guangzhou, 510632, China , Guangzhou (China)
  • 2 Southern Medical University, Guangzhou, 510515, China , Guangzhou (China)
  • 3 The University of Texas MD Anderson Cancer Center & University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77054, USA , Houston (United States)
Type
Published Article
Journal
Reproductive Biology and Endocrinology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Nov 28, 2019
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12958-019-0547-y
Source
Springer Nature
Keywords
License
Green

Abstract

As the largest family of E3 ligases, the Skp1-cullin 1-F-box (SCF) E3 ligase complex is comprised of Cullins, Skp1 and F-box proteins. And the SCF E3 ubiquitin ligases play an important role in regulating critical cellular processes, which promote degradation of many cellular proteins, including signal transducers, cell cycle regulators, and transcription factors. We review the biological roles of the SCF ubiquitin-ligase complex in gametogenesis, oocyte-to-embryo transition, embryo development and the regulation for estrogen and progestin. We find that researches about the SCF ubiquitin-ligase complex at the beginning of life are not comprehensive, thus more in-depth researches will promote its eventual clinical application.

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