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The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke

Authors
  • Sprödhuber, Andrea
  • Wolz, Johannes
  • Budai, Attila
  • Laumeier, Inga
  • Audebert, Heinrich J.
  • Michelson, Georg
Type
Published Article
Journal
Ophthalmic Research
Publisher
S. Karger AG
Publication Date
Jun 06, 2018
Volume
60
Issue
1
Pages
1–8
Identifiers
DOI: 10.1159/000488491
PMID: 29874669
Source
Karger
Keywords
License
Green
External links

Abstract

Objectives: To measure the density of retinal vessels from digitized fundus photographs in patients with recent stroke and age-matched controls. To investigate whether the parameter retinal vascular density (RVD) served as a quantitative marker for cerebrovascular events. Methods: Digitized fundus photographs of n = 158 subjects with stroke or transient ischemic attack within 1 year at the time of examination and n = 1,250 age-matched controls without any remarkable medical history were examined. Sex, hypertension, and diabetes were considered to be cofactors. Measurement of RVD was performed with a computer-aided image-analyzing program by segmenting automatically all visible retinal vessels and measuring areas of vessels in distinct circles around the optic disk. Results: In controls RVD dwindles with increasing distance from the optic disk. RVD decreased significantly with age (p = 0.000). Stroke patients showed significantly lower values of RVD of –15% in comparison to age-matched controls. In old subjects, stroke in combination with hypertension is associated with a significant decreased RVD, and in middle-aged subjects diabetes and stroke are associated with a significant decreased RVD (p = 0.01). Conclusion: Age and stroke are significant risk factors for decreased RVD. Diabetes and arterial hypertension are additional significant risk factors in patients with stroke with respect to RVD.

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