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[The role of regulatory T cells in allergic contact dermatitis].

Authors
  • Krecisz, Beata
  • Chomiczewska, Dorota
  • Kieć-Swierczyńska, Marta
Type
Published Article
Journal
Medycyna pracy
Publication Date
Jan 01, 2009
Volume
60
Issue
4
Pages
315–319
Identifiers
PMID: 19928431
Source
Medline
License
Unknown

Abstract

Regulatory T cells (Treg) play a crucial role in the regulatory mechanisms of immune system. They are responsible for the induction and maintenance of immune tolerance. They are also involved in the pathogenesis of autoimmune and allergic diseases and implicated in transplant rejection and immunopathology of cancers. Treg cells constitute the population of lymphocytes heterogeneous in their phenotype. CD4+CD25+Foxp3+ cells are most important among Treg subsets. Modification of Treg actvity may be useful in the therapy of different diseases, including allergic disorders.

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