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The role of qSOFA score and biomarkers in assessing severity of community-acquired pneumonia in adults

Authors
  • Tripon, Raluca-Elena1
  • Cristea, Victor2
  • Lupse, Mihaela-Sorina3
  • 1 “Iuliu Hatieganu” University of Medicine and Pharmacy; Teaching Hospital of Infectious Diseases, Romania , (Romania)
  • 2 “Iuliu Hatieganu” University of Medicine and Pharmacy, Romania , (Romania)
  • 3 “Iuliu Hatieganu” University of Medicine and Pharmacy;Teaching Hospital of Infectious Diseases, Romania , (Romania)
Type
Published Article
Journal
Revista Romana de Medicina de Laborator
Publisher
De Gruyter Open Sp. z o.o.
Publication Date
Jan 01, 2021
Volume
29
Issue
1
Pages
65–75
Identifiers
DOI: 10.2478/rrlm-2020-0038
Source
De Gruyter
Keywords
License
Green

Abstract

Introduction: Community-acquired pneumonia (CAP) is the primary cause of severe sepsis. Severity assessment scores have been created, in order to help physicians decide the proper management of CAP. The purpose of this study was to examine the correlations between different CAP severity scores, including qSOFA, several biomarkers and their predictive value in the 30 day follow-up period, regarding adverse outcome. Materials and methods: One hundred and thirty nine adult patients with CAP, admitted in the Teaching Hospital of Infectious Diseases, Cluj-Napoca, Romania from December 2015 to February 2017, were enrolled in this study. Pneumonia Severity Index (PSI), CURB-65, SMART-COP and the qSOFA scores were calculated at admittance. Also, C-reactive protein (CRP), procalcitonin (PCT) and albumin levels were used to determine severity. Results: The mean PSI of all patients was 93.30±41.135 points, for CURB-65 it was 1.91±0.928 points, for SMART-COP it was 1.69±1.937 points. The mean qSOFA was 1.06±0.522 points, 21 (14.9%) were at high risk of in-hospital mortality. In the group of patients with qSOFA of ≥2, all pneumonia severity scores and all biomarkers tested were higher than those with scores <2. We found significant correlations between biomarkers and severity scores, but none regarding adverse outcome. Conclusion: The qSOFA score is easier to use and it is able to accurately evaluate the severity of CAP, similar to other scores. Biomarkers are useful in determining the severity of the CAP. Several studies are needed to assess the prediction of these biomarkers and severity scores in pneumonia regarding adverse outcome.

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