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Role of pyroptosis in spinal cord injury and its therapeutic implications.

Authors
  • Al Mamun, Abdullah1
  • Wu, Yanqing2
  • Monalisa, Ilma3
  • Jia, Chang4
  • Zhou, Kailiang5
  • Munir, Fahad6
  • Xiao, Jian1
  • 1 Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035 Zhejiang Province, China. , (China)
  • 2 Institute of Life Sciences, Wenzhou University, Wenzhou, 325035 Zhejiang Province, China. , (China)
  • 3 Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh. , (Bangladesh)
  • 4 Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, China. , (China)
  • 5 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027 Zhejiang Province, China. , (China)
  • 6 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang Province, China. , (China)
Type
Published Article
Journal
Journal of advanced research
Publication Date
Feb 01, 2021
Volume
28
Pages
97–109
Identifiers
DOI: 10.1016/j.jare.2020.08.004
PMID: 33364048
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Currently, spinal cord injury (SCI) is a pathological incident that triggers several neuropathological conditions, leading to the initiation of neuronal damage with several pro-inflammatory mediators' release. However, pyroptosis is recognized as a new programmed cell death mechanism regulated by the stimulation of caspase-1 and/or caspase-11/-4/-5 signaling pathways with a series of inflammatory responses. Our current review concisely summarizes the potential role of pyroptosis-regulated programmed cell death in SCI, according to several molecular and pathophysiological mechanisms. This review also highlights the targeting of pyroptosis signaling pathways and inflammasome components and its therapeutic implications for the treatment of SCI. Multiple pieces of evidence have illustrated that pyroptosis plays significant roles in cell swelling, plasma membrane lysis, chromatin fragmentation and intracellular pro-inflammatory factors including IL-18 and IL-1β release. In addition, pyroptosis is directly mediated by the recently discovered family of pore-forming protein known as GSDMD. Current investigations have documented that pyroptosis-regulated cell death plays a critical role in the pathogenesis of multiple neurological disorders as well as SCI. Our narrative article suggests that inhibiting the pyroptosis-regulated cell death and inflammasome components could be a promising therapeutic approach for the treatment of SCI in the near future. © 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

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