Affordable Access

deepdyve-link
Publisher Website

The Role of polyphenols in the modulation of plasma Non-Enzymatic Antioxidant Capacity (NEAC).

Authors
  • Serafini, Mauro
  • Morabito, Giuseppa
Type
Published Article
Journal
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Publication Date
Jun 01, 2012
Volume
82
Issue
3
Pages
228–232
Identifiers
DOI: 10.1024/0300-9831/a000116
PMID: 23258405
Source
Medline
License
Unknown

Abstract

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

Report this publication

Statistics

Seen <100 times