Affordable Access

Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis.

Authors
  • Virmani, J
  • Johnson, E N
  • Klein-Szanto, A J
  • Funk, C D
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 26, 2001
Volume
162
Issue
2
Pages
161–165
Identifiers
PMID: 11146221
Source
Medline
License
Unknown

Abstract

Murine and human skin express an abundance of lipoxygenase isoforms whose functions are not understood. Substantial data have implicated a role for the 'platelet-type' 12-lipoxygenase (P-12LO) metabolite, 12(S)-hydroxy-eicosatetraenoic acid (12-HETE), in a variety of tumor functions. Using P-12LO deficient mice, we sought to examine the role of the P-12LO pathway in tumor initiation and progression. Two distinct genetic strains of P-12LO deficient and wild-type mice, B6/129 Sv and SENCAR, were evaluated in two-stage carcinogenesis experiments. Carcinoma incidence was significantly reduced in the P-12LO deficient mice of the B6/129 Sv background but not the SENCAR-backcrossed mice. In contrast, papilloma incidence was reduced on the SENCAR background but not in the B6/129 Sv strain mice. A separate experiment employing a complete carcinogenesis protocol failed to find any difference in papilloma or carcinoma incidence. Overall, these data suggest that the P-12LO pathway may contribute to tumor incidence and progression in two-stage, but not complete, carcinogenesis, depending on the genetic background.

Report this publication

Statistics

Seen <100 times