Our data suggest that enhanced expression of PlGF and flt-1 may contribute to rheumatoid inflammation by triggering production of proinflammatory cytokines. The use of the novel anti-flt-1 peptide, GNQWFI, may be an effective strategy for the treatment of RA.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/19180491