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Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation.

Authors
  • Yoo, Seung-Ah
  • Yoon, Hyung-Ju
  • Kim, Hyun-Sook
  • Chae, Chi-Bom
  • De Falco, Sandro
  • Cho, Chul-Soo
  • Kim, Wan-Uk
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Feb 01, 2009
Volume
60
Issue
2
Pages
345–354
Identifiers
DOI: 10.1002/art.24289
PMID: 19180491
Source
Medline
License
Unknown

Abstract

Our data suggest that enhanced expression of PlGF and flt-1 may contribute to rheumatoid inflammation by triggering production of proinflammatory cytokines. The use of the novel anti-flt-1 peptide, GNQWFI, may be an effective strategy for the treatment of RA.

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