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[Role of peroxides in changes in brain mitochondria energy metabolism following exposure to schizophrenic patients' serum].

Authors
  • Gulidova, G P
Type
Published Article
Journal
Biulleten' eksperimental'noĭ biologii i meditsiny
Publication Date
Jul 01, 1981
Volume
92
Issue
7
Pages
42–44
Identifiers
PMID: 7295943
Source
Medline
License
Unknown

Abstract

Antioxidants normalize some of the characteristics of energy metabolism in mitochondria from the rat cerebral cortex, altered as a result of exposure to blood serum from patients suffering from continuous schizophrenia. Meanwhile, antioxidants proved little effective after administration of blood serum from patients with attach-like schizophrenia. The whole blood serum and low-molecular fractions (ultrafiltrate, protein-free) obtained from it (the first group of patients) increased the intensity of malonic dialdehyde accumulation by the test system, whereas in the second group of patients, this process, exposed to the analogous blood fractions, proceeded less violently. It is concluded that one of the reasons for alterations in energy metabolism exposed to blood serum from patients with continuous schizophrenia is the toxic action of peroxidation products.

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