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Role of paraxial mesoderm in limb/flank regionalization of the trunk lateral plate.

Authors
  • Noro, Miyuki
  • Yuguchi, Hiroki
  • Sato, Taeko
  • Tsuihiji, Takanobu
  • Yonei-Tamura, Sayuri
  • Yokoyama, Hitoshi
  • Wakamatsu, Yoshio
  • Tamura, Koji
Type
Published Article
Journal
Developmental Dynamics
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 01, 2011
Volume
240
Issue
7
Pages
1639–1649
Identifiers
DOI: 10.1002/dvdy.22666
PMID: 21608076
Source
Medline
License
Unknown

Abstract

To understand the developmental mechanism that determines limb size and the consequent limb-to-trunk proportions in the tetrapod body, we investigated the role of the paraxial mesoderm in the specification of the limb and flank fields in the chick embryo. We found that the paraxial mesoderm subjacent to the limb field can affect the size of the limb bud along the anterior-posterior and proximal-distal axes. We also found that the paraxial mesoderm subjacent to the flank plays roles in suppressing the emergence and growth of the limb bud and in promoting flank-specific apoptosis in the lateral plate mesoderm. Our results suggest that signals from the paraxial mesoderm specify the limb and flank fields in the competent lateral plate mesoderm.

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