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The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases

Authors
  • Li, Mei1
  • 1 Nanjing Agricultural University,
Type
Published Article
Journal
APOPTOSIS
Publisher
Springer-Verlag
Publication Date
Mar 30, 2021
Volume
26
Issue
5-6
Pages
235–247
Identifiers
DOI: 10.1007/s10495-021-01667-z
PMID: 33783663
PMCID: PMC8197724
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits mitochondrial apoptosis under treatment with radiation and chemotherapy. It also induces excessive apoptosis in cardiovascular and/or neurodegenerative diseases. PUMA has been found to play a critical role in ovarian apoptosis. In the present paper, we review the progress of the study in PUMA over the past two decades in terms of its inducement and/or amplification of programmed cell death and describe recent updates to the understanding of both P53-dependent and P53-independent PUMA-mediated apoptotic pathways that are implicated in physiology and pathology, including the development of the ovary and cardiovascular and neurodegenerative diseases. We propose that PUMA may be a key regulator during ovary development, provide a model for PUMA-mediated apoptotic pathways, including intrinsic and extrinsic apoptotic pathways.

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