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The Role of Oxytocin Receptor (OXTR) Gene Polymorphisms in the Development of Aggressive Behavior in Healthy Individuals

Authors
  • Davydova, Yu. D.1
  • Kazantseva, A. V.1
  • Enikeeva, R. F.1
  • Mustafin, R. N.2
  • Lobaskova, M. M.3
  • Malykh, S. B.3
  • Gilyazova, I. R.1, 2
  • Khusnutdinova, E. K.1, 2
  • 1 Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences, Ufa, 450054, Russia , Ufa (Russia)
  • 2 Bashkir State Medical University, Ufa, 450008, Russia , Ufa (Russia)
  • 3 Psychological Institute, Russian Academy of Education, Moscow, 125009, Russia , Moscow (Russia)
Type
Published Article
Journal
Russian Journal of Genetics
Publisher
Pleiades Publishing
Publication Date
Sep 23, 2020
Volume
56
Issue
9
Pages
1129–1138
Identifiers
DOI: 10.1134/S1022795420090057
Source
Springer Nature
Keywords
License
Yellow

Abstract

AbstractOxytocin represents one of the key element regulating social activity and aggressive behavior via its binding to oxytocin receptor (OXTR). Considering the multifactorial nature of developing aggression, the present study aimed to assess the main effects of the OXTR (rs53576, rs237911, rs7632287, rs2254298, rs2228485, rs13316193) gene polymorphisms together with haplotypic and G × E effects on individual differences in aggression level in 623 mentally healthy individuals with sex and ethnicity as covariates. The association of rs2228485*G allele (PFDR = 0.046) and rs237911*G allele (PFDR = 0.046) and decreased aggression level was observed in Tatars. Haplotypic analysis revealed an association of the OXTR G*G*G haplotype (rs53576, rs2228485, and rs237911) and diminished aggression level (Pperm = 0.020) in Tatars. As a result of multiple regression analysis, we observed the modulating effect of smoking and paternal overprotection significantly affecting association of the OXTR rs2228485 and aggression level (P = 0.029 and P = 0.014, respectively) in the total sample.

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