Affordable Access

Role of oxidative stress and inflammation in the origin of Type 2 diabetes--a paradigm shift.

Authors
Type
Published Article
Journal
Expert Opinion on Therapeutic Targets
1472-8222
Publisher
Informa UK (Ashley Publications)
Publication Date
Volume
8
Issue
5
Pages
401–408
Identifiers
PMID: 15469391
Source
Medline

Abstract

In Type 2 diabetes the body either produces too little insulin, or does not respond well to it. Current pharmacological treatments, which are less than optimal, either target defective insulin secretion (sulfonylureas, glinides) or insulin resistance (metformin, thiazolidinediones). Exciting new research is now helping us to understand novel pathways that may contribute to defective insulin secretion as well as decreased response to insulin. Such pathways may explain the development of diabetes and associated complications (atherosclerosis and diabetic nephropathy). Understanding the way a cell metabolises glucose may be the key to understanding how cells secrete insulin and respond to it.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F