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The role of the oxidative state of glutathione and glutathione-related enzymes in anemia of hemodialysis patients.

Authors
  • Paşaoğlu, H
  • Muhtaroğlu, S
  • Güneş, M
  • Utaş, C
Type
Published Article
Journal
Clinical Biochemistry
Publisher
Elsevier
Publication Date
Dec 01, 1996
Volume
29
Issue
6
Pages
567–572
Identifiers
PMID: 8939405
Source
Medline
License
Unknown

Abstract

The findings suggest that: 1. Low GSH is related to decreased G-6-PD activities. 2. The reduction of peroxides with GPX are decreased by low GSH and low GPX activity. 3. GSSG may react with hemoglobin and causes protein aggregation in erythrocytes. These alterations cause hemolysis and could play a role in the pathogenesis of anemia in hemodialyzed patients.

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