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Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction

Authors
Journal
Reproductive Biology and Endocrinology
1477-7827
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
2
Issue
1
Identifiers
DOI: 10.1186/1477-7827-2-75
Source
Legacy
Keywords
  • Review
Disciplines
  • Biology

Abstract

Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is one of the most important events that occur during capacitation. In this article, we have reviewed the data from our and other laboratories, and have constructed a heuristic model for the mechanisms and molecules involved in capacitation/acrosome reaction.

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