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Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in Mammals

Authors
  • Kulikova, V. A.1, 2, 3
  • Nikiforov, A. A.2
  • 1 Peter the Great St. Petersburg Polytechnic University, Saint Petersburg, 195251, Russia , Saint Petersburg (Russia)
  • 2 Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, 194064, Russia , Saint Petersburg (Russia)
  • 3 Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, 194223, Russia , Saint Petersburg (Russia)
Type
Published Article
Journal
Biochemistry (Moscow)
Publisher
Pleiades Publishing
Publication Date
Aug 10, 2020
Volume
85
Issue
8
Pages
883–894
Identifiers
DOI: 10.1134/S0006297920080040
Source
Springer Nature
Keywords
License
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Abstract

AbstractProteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In mammals, NUDTs exhibit a wide range of functions and are characterized by different substrate specificity and intracellular localization. They control the concentration of various metabolites in the cell, including key regulatory molecules such as nicotinamide adenine dinucleotide (NAD), ADP-ribose, and their derivatives. In this review, we discuss the role of NUDT proteins in the metabolism of NAD and ADP-ribose in human and animal cells.

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