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Role of mitochondria in the mechanisms of glutamate toxicity.

Authors
  • 1
  • 1 Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia. [email protected]
Type
Published Article
Journal
Biochemistry. Biokhimiia
Publication Date
Volume
70
Issue
6
Pages
611–618
Identifiers
PMID: 16038602
Source
Medline
License
Unknown

Abstract

Current data on glutamate-induced functional and morphological changes in mitochondria correlating with or being a result of their membrane potential changes are reviewed. The important role of Ca2+, Na+, and H+ in the potentiation of such changes is considered. It is assumed that glutamate-induced loss of mitochondrial potential is mediated by Ca2+ overload resulting in the induction of nonspecific permeability of the inner mitochondrial membrane.

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