Role of mitochondria in the mechanisms of glutamate toxicity.
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia. [email protected]
- Published Article
- Publication Date
Jun 01, 2005
Current data on glutamate-induced functional and morphological changes in mitochondria correlating with or being a result of their membrane potential changes are reviewed. The important role of Ca2+, Na+, and H+ in the potentiation of such changes is considered. It is assumed that glutamate-induced loss of mitochondrial potential is mediated by Ca2+ overload resulting in the induction of nonspecific permeability of the inner mitochondrial membrane.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16038602