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The role of miRNAs in COVID-19 disease

Authors
  • Fani, Mona1
  • Zandi, Milad2, 3
  • Ebrahimi, Saeedeh4
  • Soltani, Saber2, 3
  • Abbasi, Samaneh5
  • 1 Department of Pathobiology & Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  • 2 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • 3 Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  • 4 Department of Medical Microbiology, Faculty of Medicine Science, Kerman University of Medical Sciences, Kerman, Iran
  • 5 Abadan Faculty of Medical Science, Abadan, Iran
Type
Published Article
Journal
Future Virology
Publisher
Future Medicine
Publication Date
Mar 24, 2021
Identifiers
DOI: 10.2217/fvl-2020-0389
PMCID: PMC7989380
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

Nowadays, the SARS Coronavirus 2 (SARS-CoV-2) infection is recognized as the primary cause of mortality in humans. SARS-CoV-2 is transmitted through human-to-human contact and is asymptomatic in most patients. In addition to approved vaccines against SARS-CoV-2 infection, miRNAs may also be promising options against this new virus. miRNAs are small and noncoding RNAs 18–25 nucleotides in length that target the mRNAs to degrade them or obstruct their translation miRNAs act as an observer in cells. This study reviewed the literature on the potential role of cellular miRNAs in the SARS-CoV-2-host interplay as a therapeutic option in COVID-19 patients.

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