Affordable Access

Access to the full text

The Role of MiR-124 in Bladder Cancer – A Review of the Literature

Authors
  • Petcu, Costin1, 2
  • Baston, Catalin1, 2
  • Angelescu, Emil1, 2
  • Iacob, Maria Mirela3
  • Constantinescu, Ileana3, 1
  • Sinescu, Ioanel1, 2
  • 1 “Carol Davila” University of Medicine and Pharmacy, Romania , (Romania)
  • 2 Center of Uronephrology and Kidney Transplant, Fundeni Clinical Institute, Romania , (Romania)
  • 3 Center of Immunogenetics and Virology, Fundeni Clinical Institute, Romania , (Romania)
Type
Published Article
Journal
Revista Romana de Medicina de Laborator
Publisher
De Gruyter Open Sp. z o.o.
Publication Date
Jan 01, 2021
Volume
29
Issue
1
Pages
9–18
Identifiers
DOI: 10.2478/rrlm-2021-0001
Source
De Gruyter
Keywords
License
Green

Abstract

MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular functions. A growing number of studies suggest the abnormal expression of microRNAs in different types of cancer cells. MiRNA-124 is a microRNA that is down-regulated in many types of cancer cells, including bladder cancer. Our objective is to provide a review of the key publications that studied the effect of miR-124 on bladder cancer. This review focus on the targets and different pathways of miR-124 that were identified in various studies and differences between their expressions in normal urothelium and tumor tissues. We also include data regarding urinary methylations levels of miR-124 and their role in bladder cancer diagnosis and prognosis. Subsequently, we establish future perspectives of miR-124 research and its promising role in bladder cancer.

Report this publication

Statistics

Seen <100 times