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The role of microglia in multiple sclerosis.

Authors
  • Luo, Chun1
  • Jian, Chongdong1
  • Liao, Yuhan1
  • Huang, Qi1
  • Wu, Yuejuan1
  • Liu, Xixia1
  • Zou, Donghua2
  • Wu, Yuan1
  • 1 Department of Neurology, The First Affiliated Hospital of Guangxi Medical University.
  • 2 Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University and The First People's Hospital of Nanning, Nanning, People's Republic of China. , (China)
Type
Published Article
Journal
Neuropsychiatric Disease and Treatment
Publisher
Dove Medical Press
Publication Date
Jan 01, 2017
Volume
13
Pages
1661–1667
Identifiers
DOI: 10.2147/NDT.S140634
PMID: 28721047
Source
Medline
Keywords
License
Unknown

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings.

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