The role of microglia in multiple sclerosis.
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University.
Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University and The First People's Hospital of Nanning, Nanning, People's Republic of China.
- Published Article
Neuropsychiatric Disease and Treatment
Dove Medical Press
- Publication Date
Jan 01, 2017
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings.
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This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/28721047