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Role of mechanical stretching and lipopolysaccharide in early apoptosis and IL-8 of alveolar epithelial type II cells A549.

Authors
  • Ning, Qiao-Ming
  • Sun, Xiao-Ning
  • Zhao, Xin-Kai
Type
Published Article
Journal
Asian Pacific Journal of Tropical Medicine
Publisher
Medknow Publications
Publication Date
Aug 01, 2012
Volume
5
Issue
8
Pages
638–644
Identifiers
DOI: 10.1016/S1995-7645(12)60131-X
PMID: 22840453
Source
Medline
License
Unknown

Abstract

Mechanical stretch can induce the early apoptosis and IL-8 secretion. Mechanical stretch and LPS have an addictive effect on the early apoptosis and IL-8 production in alveolar type 2 cells, which is one of the mechanisms of ventilator-induced lung injury.

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