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Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria.

Authors
  • Niu, Aping1
  • Bian, Wan-Ping2
  • Feng, Shuang-Long2
  • Pu, Shi-Ya3
  • Wei, Xing-Yi4
  • Yang, Yi-Fan5
  • Song, Li-Yan2
  • Pei, De-Sheng6
  • 1 Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; College of Resources and Environmental Engineering, Guizhou University, Guizhou, 550025, China. , (China)
  • 2 Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China. , (China)
  • 3 Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; University of Chinese Academy of Sciences, Beijing, 100049, China. , (China)
  • 4 Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; School of River and Ocean Engineering, Chongqing Jiaotong University, Chongqing 400074, China. , (China)
  • 5 Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; College of Life Science, Henan Normal University, Xinxiang, 453007, China. , (China)
  • 6 Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China; College of Life Science, Henan Normal University, Xinxiang, 453007, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of hazardous materials
Publication Date
Aug 02, 2020
Volume
403
Pages
123604–123604
Identifiers
DOI: 10.1016/j.jhazmat.2020.123604
PMID: 32781281
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The toxicity of Cr(VI) was widely investigated, but the defense mechanism against Cr(III) in bacteria are seldom reported. Here, we found that Cr(III) inhibited bacterial growth and induced reactive oxygen species (ROS). After exposure to Cr(III), loss of sodA not only led to the excessive generation of ROS, but also enhanced the level of lipid peroxidation and reduced the GSH level, indicating that the deficiency of Mn-SOD decreased the bacterial resistance ability against Cr(III). The adverse effects of oxidative stress caused by Cr(III) could be recovered by the rescue of Mn-SOD in the sodA-deficient strain. Besides the oxidative stress, Cr(III) could cause the bacterial morphology variation, which was distinct between the wild-type and the sodA-deficient strains due to the differential expressions of Z-ring division genes. Moreover, Mn-SOD might prevent Cr(III) from oxidation on the bacterial surface by combining with Cr(III). Taken together, our results indicated that the Mn-SOD played a vital role in regulating the stress resistance, expression of cell division-related genes, bacterial morphology, and chemistry valence state of Cr. Our findings firstly provided a more in-depth understanding of Cr(III) toxicity and bacterial defense mechanism against Cr(III). Copyright © 2020 Elsevier B.V. All rights reserved.

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