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The role of macrophages and immunocytes in the pathogenesis of pulmonary diseases due to mineral dusts.

Authors
  • Pernis, B
  • Vigliani, E C
Type
Published Article
Journal
American journal of industrial medicine
Publication Date
Jan 01, 1982
Volume
3
Issue
2
Pages
133–137
Identifiers
PMID: 6291383
Source
Medline
License
Unknown

Abstract

There is considerable evidence of generalized stimulation of the immune system in pulmonary dust diseases. This stimulation involves both the T- and the B-arms of the immune system. A reasonable explanation of this immune stimulation resides in an effect of the mineral dusts on the macrophages. This effect is likely to be mediated by the production of interleukin-1. Since the same substance also stimulates fibroblasts, a unified view of the pathogenesis of pulmonary dust diseases is now possible.

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